How brain cell damage causes weakness, numbness, loss of sensation and pricking pain in diabetes
Diabetes damages neuronal cells in areas like the hippocampus
and cortex in the brain at high and low blood sugar levels. High blood sugar
damages the brain blood vessels, blocking oxygen supply to brain cells, while
low blood sugar levels directly cause neuronal death. In diabetes silent brain
injury occurs, and white matter lesions cause inflammation, lead to fast damage.
In diabetes symptoms like burning, numbness, weakness, and
loss of sensation occur due to damaged nerve cells in the body, especially in
the peripheral nerves in the feet and hands.
Insulin
Resistance
In diabetes, mitochondrial dysfunction involves disrupted
energy production, increased reactive oxygen species, and disturbed cellular
metabolism, which leads to insulin resistance. This malfunction is because of
genetic factors and various environmental toxins, which cause impaired glucose
metabolism, disrupting the processes of insulin signaling-stimulated insulin secretion.
How
peripheral nerve damage.
High blood sugar levels and low supply of blood to peripheral
nerves cause damage, which causes inflammation and impaired nerve function.
In
diabetes, first small nerve fibers and the small blood vessels are affected;
that damage leads to problems with pain and temperature sensation. Damage to
small blood vessels affects the kidneys, eyes, and other organs.
Chronic diabetes
When diabetes is in progress and proper nerve supply is
disturbed, the affected nerve fibers lead to loss of sensation and reflexes,
typically starting in the toes and feet and extending upward.
Important strategies for maintaining healthy blood sugar
levels through diet, medication, and exercise. Regular checking of blood sugar levels
can reduce vessel and nerve damage.
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